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  • 1.  Cabenuva + lenacapravir for rilpivirine resistance

    Posted 07-31-2025 21:37

    Has anyone used Cabenuva (with or without the rilpivirine portion) with lenacapravir as a complete regimen in someone with rilpivirine resistance and inability to adhere to oral therapy (also single digit CD4 and severe anal dysplasia)? 



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    Victoria Lieb
    Easton PA
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  • 2.  RE: Cabenuva + lenacapravir for rilpivirine resistance

    Posted 08-01-2025 17:12

    I have four patients on a CAB/LEN regimen, all with RPV resistance and inability to adhere to PO medication regimen. I have worked with the UCSF warmline for all of them before initiation, and they are actually all doing really well and are virally suppressed. I'd encourage you to contact the warmline and run it by one of the providers there if you have questions about the appropriateness for your patient. The number is 1-800-933-3413, and the service is also available online through the AETC app.

     

                                                                     

    Deborah Fredell-Gonzalez, PA-C, AAHIVS (she,her)

    Physician Assistant, NIDO Clinic, Clinic Services Bureau

    Monterey County Department of Health

    Phone 831-796-1770, Fax 831-422-5979

    County of Monterey EmblemCounty of Monterey LGBTQ+ Special Markersafespace

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  • 3.  RE: Cabenuva + lenacapravir for rilpivirine resistance

    Posted 08-02-2025 16:24
      |   view attached

    There is at least one published case series looking at this combination (attached). I don't know what the status is on a clinical trial. I know of some clinics that have convinced insurers to pay for Apretude when there is rilpivirine resistance to avoid wasting the rllpivirine in Cabenuva.



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    Joel Gallant, MD, MPH
    Johns Hopkins University
    Baltimore, MD

    AXCES Research Group
    Santa Fe, NM
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    Attachment(s)

    pdf
    CAB-LEN.pdf   410 KB 1 version