Academy Exchange

Good evening,

Curious if there is any good guidance out there on counseling for leaking of LEN following injection. 
Just had this happen in clinic today. The leak was significant enough to saturate band aid, and a couple 2x2 gauze pads. 

In the moment, I instructed them to continue their oral PrEP, and plan to follow up with them in the next couple of days for further instructions.

Is there any drug level lab commercially available? Anything available through the manufacturer?

Strategies to help mitigate this?

Thanks in advance!

Good evening,

Curious if there is any good guidance out there on counseling for leaking of LEN following injection. 
Just had this happen in clinic today. The leak was significant enough to saturate band aid, and a couple 2x2 gauze pads. 

In the moment, I instructed them to continue their oral PrEP, and plan to follow up with them in the next couple of days for further instructions.

Is there any drug level lab commercially available? Anything available through the manufacturer?

Strategies to help mitigate this?

Thanks in advance!

Hi Trevor,

We have had this happen to us once in our clinic as well. Our RN estimated that half of the total volume of Yeztugo was extruded after administering the injections. After we assured the manufacturer that our nursing staff was well versed in administering LEN (we've been using Sunlenca for some time without issues) they recommended administering another half dose which they were willing to provide, but recommended continuing to use oral PrEP in the meantime. Our patient was transitioning from Apretude and we had planned approximately a week of overlap, so we felt comfortable that he was covered while we figured it out. In the end, the patient was put off enough by the experience that he decided to stick with Apretude. The MSL for ViiV said there were only 4 cases of significant leaking documented during the approval phase so they didn't have a lot of data to go on. What is significant? We would like to know this too. The bottom line is to keep the patient protected with some other form of PrEP, as you did.

Good evening,

Curious if there is any good guidance out there on counseling for leaking of LEN following injection. 
Just had this happen in clinic today. The leak was significant enough to saturate band aid, and a couple 2x2 gauze pads. 

In the moment, I instructed them to continue their oral PrEP, and plan to follow up with them in the next couple of days for further instructions.

Is there any drug level lab commercially available? Anything available through the manufacturer?

Strategies to help mitigate this?

Thanks in advance!

Good evening,

Curious if there is any good guidance out there on counseling for leaking of LEN following injection. 
Just had this happen in clinic today. The leak was significant enough to saturate band aid, and a couple 2x2 gauze pads. 

In the moment, I instructed them to continue their oral PrEP, and plan to follow up with them in the next couple of days for further instructions.

Is there any drug level lab commercially available? Anything available through the manufacturer?

Strategies to help mitigate this?

Thanks in advance!