My providers and I have ongoing discussion when HIV patients have the following HBV serologic profiles:
1) HBV Core Ab (+), HBV Surface Ab (+), and HBV Surface Ag (-)
2) HBV Core Ab (+), HBV Surface Ab (-), and HBV Surface Ag (-) ... these results have been confirmed (not a false-positive Core Ab)
Scenario #1) We all agree that these serologies are telling us that the patient has HBV immunity due to natural infection; however, due to HBV Core Ab (+), does this still warrant the need for the patient's ART regimen to include 2 (or even 1) HBV-active NRTI agent? Based on some non-HIV guidelines (i.e., NCCN and AASLD), they recommend HBV prophylaxis for patients with sole HBV Core Ab positivity to prevent HBV reactivation. Based on this, some of our providers will still advocate for ART regimens that include 2 HBV-active agents or even add entecavir to ART regimens without HBV activity (i.e., Juluca). However in theory, there is no risk for HBV infection/reactivation since they're naturally immune (HBsAb +)?
Scenario #2) Since this serologic profile could represent resolved infection (without an antibody response), low level chronic or resolving active infection, this patient would be at risk for HBV infection / reverse seroconversion. In either case, this patient should receive ART that has activity against HBV.
My overarching question: would you handle these two HBV Core Ab(+) serologies differently in terms of ART? Or just give ART with 2 HBV-active NRTI agents to all HBV Core Ab(+) patients to be on the safe side?
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Nick Piccicacco, PharmD, BCIDP, AAHIVP
Tampa, FL
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