I would ask that someone address in detail the recently released new CDC Guidelines for PrEP in the next issue, if not already doing such, in the next edition of HIV Specialist and in an upcoming Academy Voice email
Good thing that the HIV RNA qualitative does not require refrigerated or frozen blood, unlike the HIV RNA quantitative (Viral Load).
With the new suggested guidelines of always having a negative HIV RNA qualitative confirmatory test….it seems to me that we might also alter the PEP Guidelines and protocol. Specifically, if a 6 week post PEP initiation lab shows a negative HIV RNA, after taking PEP meds for 28 days, would that not be enough to "close the case", instead of doing a 3 month follow up?
LBrian R. McMurray, MD, FACP, AAHIVS
Music City PrEP, Medical Director
615 Main St.
Nashville, TN 37206
To clarify….the qualitative HIV RNA is less expensive than the quantitative (the Viral Load test). And importantly, the qualitative test can be performed with the sample at room temperature, whereas the quantitative (Viral Load) must be refrigerated for 24 hours before running it, or frozen if longer (per LabCorp).
I don't know if a seroconverted patient two weeks off PEP would still have a negative HIV RNA qualitative test result? We are using Biktarvy for PEP at times, like for "TelePEP" where pharmacies have Biktarvy, but not Truvada and Tivicay.