Is there any insight to starting metformin to increase CD4 count and to decrease inflammatory response in patients even without DM?

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David Farber
Rapid City SD
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This is rather interesting but not much data to support it - I did find one study in PubMed and many others that would qualify as disease oriented evidence. There is also a push to use metformin in the "anti-aging literature". I would be inclined to not do this David unless my HIV patient also had type 2 DM.

Short Communication: Metformin Reduces CD4 T Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy

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Jeffrey T. Kirchner, DO, FAAFP, AAHIVS
Lancaster PA
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Original Message:
Sent: 12-06-2023 15:08
From: David Farber
Subject: Metformin for anti inflammatory or to increase CD4

Is there any insight to starting metformin to increase CD4 count and to decrease inflammatory response in patients even without DM?

------------------------------
David Farber
Rapid City SD
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While metformin is primarily known as an oral medication for managing type 2 diabetes, there is emerging research suggesting potential benefits beyond glycemic control. Some studies have explored the impact of metformin on immune function and inflammation, including its potential role in improving CD4 counts and reducing inflammatory responses. However, it's essential to note that the evidence is not yet conclusive, and further research is needed to establish clear recommendations. It is essential to approach this topic cautiously and under the guidance of a healthcare professional.

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harry brown
Las Vegas NV
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Original Message:
Sent: 12-06-2023 15:08
From: David Farber
Subject: Metformin for anti inflammatory or to increase CD4

Is there any insight to starting metformin to increase CD4 count and to decrease inflammatory response in patients even without DM?

------------------------------
David Farber
Rapid City SD
------------------------------

That is very good information about Metformin being used as an anti-inflammatory.  Thanks, Harry

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Henry Bryant
Pembroke Pines FL
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Original Message:
Sent: 02-05-2024 12:03
From: harry brown
Subject: Metformin for anti inflammatory or to increase CD4

While metformin is primarily known as an oral medication for managing type 2 diabetes, there is emerging research suggesting potential benefits beyond glycemic control. Some studies have explored the impact of metformin on immune function and inflammation, including its potential role in improving CD4 counts and reducing inflammatory responses. However, it's essential to note that the evidence is not yet conclusive, and further research is needed to establish clear recommendations. It is essential to approach this topic cautiously and under the guidance of a healthcare professional.

------------------------------
harry brown
Las Vegas NV

Original Message:
Sent: 12-06-2023 15:08
From: David Farber
Subject: Metformin for anti inflammatory or to increase CD4

Is there any insight to starting metformin to increase CD4 count and to decrease inflammatory response in patients even without DM?

------------------------------
David Farber
Rapid City SD
------------------------------