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  • 1.  Metformin for anti inflammatory or to increase CD4

    Posted 12-06-2023 15:09

    Is there any insight to starting metformin to increase CD4 count and to decrease inflammatory response in patients even without DM?



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    David Farber
    Rapid City SD
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  • 2.  RE: Metformin for anti inflammatory or to increase CD4

    Posted 12-07-2023 16:05

    This is rather interesting but not much data to support it - I did find one study in PubMed and many others that would qualify as disease oriented evidence. There is also a push to use metformin in the "anti-aging literature". I would be inclined to not do this David unless my HIV patient also had type 2 DM.

    Randomized Controlled Trial
    . 2020 Apr;36(4):303-305.
    doi: 10.1089/AID.2019.0078. Epub 2020 Jan 8.

    Short Communication: Metformin Reduces CD4 T Cell Exhaustion in HIV-Infected Adults on Suppressive Antiretroviral Therapy

    Cecilia M Shikuma 1, Glen M Chew 2, Lindsay Kohorn 1, Scott A Souza 1, Dominic Chow 1, Ivo Novita SahBandar 2, Eun-Young Park 2, Nancy Hanks 1, Louie Mar A Gangcuangco 2, Mariana Gerschenson 3, Lishomwa C Ndhlovu 2
    Affiliations


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    Jeffrey T. Kirchner, DO, FAAFP, AAHIVS
    Lancaster PA
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    Original Message


  • 3.  RE: Metformin for anti inflammatory or to increase CD4

    Posted 02-05-2024 12:04

    While metformin is primarily known as an oral medication for managing type 2 diabetes, there is emerging research suggesting potential benefits beyond glycemic control. Some studies have explored the impact of metformin on immune function and inflammation, including its potential role in improving CD4 counts and reducing inflammatory responses. However, it's essential to note that the evidence is not yet conclusive, and further research is needed to establish clear recommendations. It is essential to approach this topic cautiously and under the guidance of a healthcare professional.



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    harry brown
    Las Vegas NV
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    Original Message


  • 4.  RE: Metformin for anti inflammatory or to increase CD4

    Posted 02-05-2024 14:51

    That is very good information about Metformin being used as an anti-inflammatory.  Thanks, Harry



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    Henry Bryant
    Pembroke Pines FL
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    Original Message